An Elegant Defense

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Matt Richtel
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William Morrow; 1 edition 2019-3-12 Hardcover 9780062699107

具體描述

Matt Richtel is a Pulitzer Prize-winning New York Times journalist and bestselling writer of mysteries and thrillers. His books are fast-paced, character-centered stories in which things are not always as they seem. The backdrop for the books is the modern world. Technology is everywhere. Everything moves at lightning speed, from conspiracy, to love, business, and violence. Technology is our slave. Or has it become our dark master?

The books relate to Matt's journalism. He won the Pulitzer Prize in 2010 for a series of stories on distracted driving. The next year, he wrote an acclaimed series for the New York Times called "Your Brain On Computers" exploring how heavy technology use impacts our behavior and our brains.

Matt lives with his family in San Francisco. He writes from an office with a window that looks onto the former house of baseball legend Willie Mays. He -- Matt, not Willie -- is an avid tennis player, takes pride in making guacamole and coffee, and writes the occasional song.

NATIONAL BESTSELLER

A grand tour of the human immune system and the secrets of health, by the Pulitzer Prize–winning New York Times journalist

“One of those rare nonfiction books that transcends the genre. ... Extraordinary.” —Douglas Preston

A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.

The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.

For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.

Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.

Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

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##要不是自己得瞭不算很嚴重的自體免疫病,我今年也不會讀好幾本關於免疫係統的書。免疫係統是如此復雜和精確,隻能說連現代醫學對它的瞭解也依然很粗糙。過去我們總把免疫係統比喻成持續不斷與病原體戰鬥的激進係統,其實是錯的。過於活躍的免疫會傷害自身造成自體免疫病,免疫係統裏也有自我刹車、調解與其他細菌和病毒和諧共處的機製。書裏一些病人的例子,在吃一種藥壓抑/提升瞭免疫後又無意中帶來一係列副作用,又需要另外的藥在天平另一端進行調整,最後往往要十幾種藥一起吃。這個“平衡”實在太難把控。書最後總結的理念有點迴歸傳統智慧的意思:講究平衡、養生、holistic,吃飽睡好多運動,人人都知道,但不一定人人能做到。(我覺得中醫的【養生理念】,注意我說的是理念,有一定道理。但如果生病瞭還是要靠現代醫學,不要吃中藥)

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##當醫生的哥哥曾和我說過一句話: 人類的身體太精密瞭,復雜到一個小問題都可能會緻命 人類的身體又太堅強瞭,其實大部分問題它自己都可以解決 這本書今年看來尤其應景,麵對地球上的幾十萬未知病毒,人類的免疫係統一直在默默地守護 但是,平衡是一切的關鍵,這個“優雅的守衛...  

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